PARTICLES CONTAINING AN ACTIVE AGENT IN THE FORM OF A CO-PRECIPITATE

摘要

Producing particles comprising a neutral hydrophilic carrier coated with a coprecipitate by spraying the carrier with an organic solution containing an active substance, a surfactant and a hydrophilic polymer comprises coating the carrier in at least two stages, each followed by a grinding step. Independent claims are also included for: (1) particles consisting of a coprecipitate applied as a layer around a neutral hydrophilic carrier and comprising an active substance, a surfactant and a hydrophilic polymer; (2) pharmaceutical dosage form comprising particles as above and optionally excipients.