| 发明名称 | MAPKAP kinase-2 as a specific target for blocking proliferation of P53-defective | ||
| 摘要 | The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorders. | ||
| 申请公布号 | US9023787(B2) | 申请公布日期 | 2015.05.05 |
| 申请号 | US201313893141 | 申请日期 | 2013.05.13 |
| 申请人 | Massachusetts Institute of Technology | 发明人 | Yaffe Michael B.;Manke Isaac A.;Reinhardt Hans Christian |
| 分类号 | A61K31/00;A61K38/16;A61K31/553;A61K45/06;C07K7/06;C07K7/08;C12N9/12;C12Q1/48;G01N33/573;G01N33/574;A61K31/7034;A61K33/24;G06F19/16;G06F19/20;G06F19/22 | 主分类号 | A61K31/00 |
| 代理机构 | Pabst Patent Group LLP | 代理人 | Pabst Patent Group LLP |
| 主权项 | 1. A method of sensitizing cells to chemotherapy comprising administering to the cells an effective amount of a MAPKAP kinase-2 polypeptide inhibitor to sensitize p53-deficient cells to a DNA damaging chemotherapeutic agent, then administering an effective amount of a chemotherapeutic to the sensitized p53-deficient cells to kill the cells wherein the chemotherapeutic agent is administered after and within twenty-eight days of administering the MAPKAP kinase-2 polypeptide inhibitor. | ||
| 地址 | Cambridge MA US | ||