| 摘要 |
<p>The present invention describes a process for selectively preparing (1H-1,2,4-triazol-1-yl)alkanols that can be used as synthesis intermediates and as pharmaceutical, veterinary and agrochemical active ingredients, and also the use of intermediates thereof, and process conditions. According to the present invention, oxiranes and halohydrins react with hydrazine (in any form, hydrates or salts) to form hydrazinyl alkanol intermediates, which are converted into (1H-1,2,4-triazol-1-yl)alkanols by reacting same with a reagent that forms 1,2,4-triazolyl. The technique discovered represents an improvement over the prior art by not allowing isomers substituted in position 4 of the triazole ring to be formed, the (1H-1,2,4-triazol-4-yl)alkanols. The methods described in the present invention are particularly advantageous over the prior art due to higher yields, shorter process times, simplification of individual processes, greater ease in recovering unreacted auxiliary materials, and complete selectivity for the formation of regioisomers.</p> |
