| 发明名称 | Assays for agents affecting megakaryocyte development | ||
| 摘要 | Methods and kits for identifying candidate anti-megakaryocyte agents are disclosed. | ||
| 申请公布号 | US9017936(B2) | 申请公布日期 | 2015.04.28 |
| 申请号 | US201012898590 | 申请日期 | 2010.10.05 |
| 申请人 | Shire Human Genetic Therapies, Inc.;University of Wales Institute, Cardiff | 发明人 | Erusalimsky Jorge D.;Ahluwalia Maninder |
| 分类号 | C12Q1/68;G01N33/53;G01N33/50 | 主分类号 | C12Q1/68 |
| 代理机构 | Choate, Hall & Stewart LLP | 代理人 | Choate, Hall & Stewart LLP ;Chen Fangli;Medina Rolando |
| 主权项 | 1. A method of identifying an anti-megakaryocyte agent comprising: contacting, a cell capable of expressing TRB-3 with an agent to be tested for anti-megakaryocyte activity; measuring expression of TRB-3 in a cell contacted with the test agent; comparing the expression of TRB-3 in a cell contacted with the test agent to a control level of expression; assessing the anti-megakaryocyte activity of a test agent which increases the expression of TRB-3 in a cell contacted with the test agent relative to the control level of expression, identifying a test agent having anti-megakaryocyte activity as an anti-megakaryocyte agent. | ||
| 地址 | Lexington MA US | ||