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1. A compound of Formula I:wherein R1 is:
H C1-C6 alkyl optionally substituted with 1-3 R4; C1-C6 alkenyl optionally substituted with 1-3 R4; C3-C6 alkynyl optionally substituted with 1-3 R4; substituted phenyl, substituted benzyl, phenyl or benzyl wherein substituents for the substituted phenyl or the substituted benzyl are selected from the group consisting of: 1-3 R5, or with a 5- or 6-membered saturated or unsaturated ring system, or with a 5-6 fused ring system, or with a 6-6 fused ring system each containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5, biphenyl or naphthyl optionally substituted with 1-3 R5; -(CHR6)mOR7; -(CHR6)mN(R9)R10; —C(═O)R8; —C(═S)R8; —S(O)2R8; —C(═O)OR8; —C(═S)OR8; -(CHR6)mN(R9)R10; —C(═O)N(R9)R10; or —C(═S)N(R9)R10;wherein m is an integer 1-4;R2 is:
H; or C1-C6 alkyl optionally substituted with R4;alternatively R1 and R2 may be taken together to form:
═CR11N(R12)R13;R3 is:
C1-C6 alkyl optionally substituted with 1-3 R4, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C2-C6 alkoxyalkyl, C2-C6 haloalkoxyalkyl, C2-C6 alkenyl optionally substituted with R14, C2-C6 haloalkenyl, C3-C6 alkynyl, substituted phenyl, substituted benzyl, phenyl or benzyl wherein substituents for the substituted phenyl or the substituted benzyl are selected from the group consisting of: 1-3 R5, or with a 5- or 6-membered saturated or unsaturated ring system, or with a 5-6 fused ring system, or with a 6-6 fused ring system each containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5, biphenyl or naphthyl optionally substituted with 1-3 R5; -(CHR6)mOR7; -(CHR6)mSR8; or —(CHR6)mN(R9)R10;R4 is independently halogen, C1-C6 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, amino, halothio, C1-C3 alkylamino, C2-C6 alkoxycarbonyl, C2-C6 alkylcarbonyl, C2-C6 alkylaminocarbonyl, hydroxyl, C3-C6 trialkylsilyl, phenyl optionally substituted with 1-3 R5, or with a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5;R5 is independently halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, halothio, amino, C1-C6 alkylamino, C2-C6 dialkylamino, C2-C6 alkoxycarbonyl, C2-C6 alkylcarbonyl, C1-C6 alkylsulfonyl, nitro, hydroxyl, or cyano;R6 is H, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R5;R7 is H, C1-C8 alkyl, C2-C6 alkenyl, C3-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxyalkyl, C2-C6 trialkylsilyl, C2-C6 trialkylsilylalkyl C2-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, substituted phenyl, substituted benzyl, phenyl or benzyl wherein substituents for the substituted phenyl or the substituted benzyl are selected from the group consisting of: 1-3 R5, or with a 5- or 6-membered saturated or unsaturated ring system, or with a 5-6 fused ring system, or with a 6-6 fused ring system each containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5, biphenyl or naphthyl optionally substituted with 1-3 R5;R8 is H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxyalkyl, substituted phenyl, substituted benzyl, phenyl or benzyl wherein substituents for the substituted phenyl or the substituted benzyl are selected from the group consisting of: 1-3 R5, or with a 5- or 6-membered saturated or unsaturated ring system, or with a 5-6 fused ring system, or with a 6-6 fused ring system each containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5, biphenyl or naphthyl optionally substituted with 1-3 R5;R9 is H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyalkyl, C2-C6 alkylcarbonyl, substituted phenyl, substituted benzyl, phenyl or benzyl wherein substituents for the substituted phenyl or the substituted benzyl are selected from the group consisting of: 1-3 R5, or with a 5- or 6-membered saturated or unsaturated ring system, or with a 5-6 fused ring system, or with a 6-6 fused ring system each containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5, biphenyl or naphthyl optionally substituted with 1-3 R5;R10 is H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyalkyl, C2-C6 alkylcarbonyl, or benzyl, wherein the benzyl may be optionally substituted with 1-3 R5;alternatively R9 and R10 may be taken together to form a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5;R11 is H or C1-C4 alkyl;R12 is H, cyano, hydroxyl, C1-C4 alkyl, C1-C6 alkoxy, C2-C6, alkylcarbonyl, phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R5; or with a 5- or 6-membered saturated or unsaturated ring system, or with a 5-6 fused ring system, or with a 6-6 fused ring system each containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5, biphenyl or naphthyl optionally substituted with 1-3 R5;alternatively R11 and R12 may be taken together to form a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5;R13 is H, C1-C4 alkyl, C1-C6 alkoxy, C2-C6, alkylcarbonyl, phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R5; or with a 5- or 6-membered saturated or unsaturated ring system, or with a 5-6 fused ring system, or with a 6-6 fused ring system each containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5, biphenyl or naphthyl optionally substituted with 1-3 R5;andalternatively R12 and R13 may be taken together to form a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R5.R14 is phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R5. |
