| 发明名称 |
SUSTAINED RELEASE FORMULATIONS OF LORAZEPAM |
| 摘要 |
A pharmaceutical composition for delivering lorazepam in a prolonged fashion is achieved with prolonged release lorazepam pharmaceutical beads. The composition typically contains sustained release lorazepam beads and delayed sustained release lorazepam beads. The composition can provide once daily dosing that maintains 24 hour therapeutic effect under steady state conditions. |
| 申请公布号 |
US2015110874(A1) |
申请公布日期 |
2015.04.23 |
| 申请号 |
US201414150375 |
申请日期 |
2014.01.08 |
| 申请人 |
Saltel Douglas A.;Vachon Michael |
发明人 |
Saltel Douglas A.;Vachon Michael |
| 分类号 |
A61K9/14;A61K9/50;A61K31/55 |
主分类号 |
A61K9/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition, comprising (i) lorazepam sustained release beads and (ii) lorazepam delayed sustained release beads, wherein the total amount of lorazepam contained in said composition is 0.5 to 10 mg and wherein said composition when administered once daily provides (1) a lorazepam blood plasma steady state Cmax that is +/−35% of the corresponding Cmax achieved by immediate release tablets given b.i.d. and having the same total daily amount of lorazepam, and/or (2) a lorazepam blood plasma steady state Cmin that is +/−35% of the corresponding Cmin achieved by immediate release tablets given b.i.d. and having the same total daily amount of lorazepam. |
| 地址 |
Austin TX US |
