发明名称 |
Cell based assays for the triglyceride synthesis pathway |
摘要 |
<p>A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled triglyceride in the presence or absence of the compound; wherein a change in the level of the stable isotope labeled triglyceride indicates that the compound modulates the DGAT activity.</p> |
申请公布号 |
AU2010210717(B2) |
申请公布日期 |
2015.04.16 |
申请号 |
AU20100210717 |
申请日期 |
2010.02.03 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
QI, JIAN-SHEN;LANG, WENSHENG;CONNELLY, MARGERY A. |
分类号 |
C12Q1/61;C12Q1/48;G01N33/50 |
主分类号 |
C12Q1/61 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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