发明名称 |
CELL ENGINEERING USING RNAs |
摘要 |
The invention concerns the field of cell culture technology. It concerns RNA having a specific sequence, expression vectors encoding said RNA, production host cell lines comprising said RNA, and methods of producing recombinant biopharmaceutical products using engineered host cell with altered levels of said RNAs, such as small non-coding RNAs, preferably microRNAs (miRNAs). The invention also relates to engineered host cells with altered levels in one or more of said RNAs. Those cell lines have improved secretion and/or growth characteristics in comparison to control cell lines. |
申请公布号 |
EP2859103(A2) |
申请公布日期 |
2015.04.15 |
申请号 |
EP20130728354 |
申请日期 |
2013.06.04 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
FLORIN, LORE;KAUFMANN, HITTO;HAUSSER, ANGELIKA;OLAYIOYE, MONILOLA;STROTBEK, MICHAELA |
分类号 |
C12N15/113;C12N15/11;C12P21/02 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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