| 发明名称 |
RECOMBINANT POLYPEPTIDES COMPRISING MHC CLASS II a1 DOMAINS |
| 摘要 |
Recombinant polypeptides comprising a DRα1 domain, an antigenic peptide, and a linker sequence are disclosed. The linker sequence comprises a first glycine-serine spacer, a thrombin cleavage site and a second glycine-serine spacer. Further disclosed are pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides. |
| 申请公布号 |
US2015098956(A1) |
申请公布日期 |
2015.04.09 |
| 申请号 |
US201414506502 |
申请日期 |
2014.10.03 |
| 申请人 |
Oregon Health & Science University ;The United States Government as Represented by the Department of Veterans Affairs |
发明人 |
Vandenbark Arthur A.;Meza-Romero Roberto;Benedek Gil;Burrows Gregory G. |
| 分类号 |
C07K14/705;C07K14/74 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant polypeptide comprising a DRα1 domain, an antigenic peptide, and a linker sequence, said linker sequence comprising a first glycine-serine spacer, a thrombin cleavage site and a second glycine-serine spacer. |
| 地址 |
Portland OR US |
