| 摘要 |
Provided herein is a method for quantifying the spatial distribution of cells or sub-cellular structures comprising (a) receiving image data comprising a plurality of biomarkers, N, wherein the data represents a spatial map of the biomarkers; (b) processing the data to obtain a set of coordinates, wherein each coordinate denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers; and (c) processing the set of coordinates into a two-dimensional symmetric (2N−1)×(2N−1) or 2N×2N matrix (D). Also provided is the use of this method for assigning subjects one or more clinical characteristics, the use of this method for forming and/or testing scientific hypotheses for one or more interventions, and apparatus comprising at least one processor configured to perform the method. |
