| 摘要 |
The present invention relates to novel nanoencapsulated compositions, methods for making such compositions, and methods of repelling insects and other arthropod pests away from animals, including humans. The present invention has particular, though not sole, application to repelling insects including flies and mosquitoes. The inventive compositions may be used to repel arthropods from animals, humans, plants, soil, or building structures. The formulations also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents. |
| 主权项 |
1. An arthropod-repellent nanoparticle formulation comprising at least one active ingredient (AI) selected from one or more coumarin derivatives according to formula (I) or (Ia): wherein R1, R2, R3, R4, and R6 independently include H, C, OR5, CR5, OCC(═O)N(R5)(R7), CC(═O)N(R5)(R7), alkyl, aryl, aralkyl, heteroaryl, alcohols, amine, aldehyde, heterocyclyl, or salts of amines and caboxylates; A is O, or the ring is opened at A, thus forming compounds according to formula (Ia); R5 and R7 are independently selected from alkyl, aryl, aralkyl, heteroaryl, alcohols, amine, aldehyde, or heterocyclyl; or R5 and R7 come together to form a C3-C10 ring, which may be aromatic, non-aromatic, and/or substituted with alkyl, aryl, aralkyl, heteroaryl, alcohols, amine, aldehyde, heterocyclyl, or combinations thereof. |
