Polyol modified aminoglycoside-lipid conjugates

摘要

In some aspects, the present invention provides aminoglycoside derivatives thereof that exhibit antibacterial activity. In some aspects, the aminoglycoside derivatives comprise compounds consisting of (a) an ammoglycoside group and (b) at least one hydrophobic carbamate and alkoxy group to the primary or secondary hydroxy position of the aminolvcoside group and salts thereof. Additionally, methods of treating and preventing bacterial infections using the aminoglycoside derivatives are also provided.

主权项

1. An aminoglycoside derivative of the following formula: wherein each R1 is H and each R2 is:
C(O)NHC6H5, C(O)NH-p-C6H4Cl, C(O)NHC6H13, C(O)NH-p-C6H4N(Me)2, CH2-p-C6H4Cl, CH2-p-C6H4C(CH3)4, or CH3; or pharmaceutically-acceptable salts thereof.