| 摘要 |
<p>The current invention exposes a method for formulating Alprazolam nanoparticles using a mucoadhesive bio-retardant which was isolated from Vitis vinifera fruits. The biopolymer revealed its inbuilt functional groups C=O and N-H. The nanoparticles showed a size range of 10-97.5nm with a promising stability, dispersibility and retardability for a period of 48hrs and the nanoparticulate dispersion showed significant anti-depressant activity due to brain specificity. The biopolymer also revealed other inbuilt novelistic property bio-Retardability. Emulsifiability and Filmability, which was confirmed by suitably formulating drug delivery dosage forms. Conclusion was drawn that bio-nanoparticulate dispersion can be used for effectively targeting to the brain via nasal route and nanoparticulate can be prepared by a novel bio-excipient from Vitis vinifera and the biopolymer can also serve as a bio-excipient for formulating various drug delivery dosage forms.</p> |
