Isolated monoclonal antibody binding to human delta-like ligand 4 (dll4), pharmaceutical compositions comprising the same, polynucleotides encoding them and use thereof in the manufacture of medicaments for the treatment of cancer

摘要

An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.