| 发明名称 |
Mutants of <i>Francisella tularensis </i>and uses thereof |
| 摘要 |
The present invention relates to a mutant Francisella tularensis strain comprising an inactivated clpB gene and compositions comprising such mutant. Methods of producing the mutant are also described. The present invention also encompasses a method of conferring immunity against F. tularensis in a host, comprising administering the described mutant F. tularensis strain. |
| 申请公布号 |
US8993302(B2) |
申请公布日期 |
2015.03.31 |
| 申请号 |
US201013266466 |
申请日期 |
2010.04.23 |
| 申请人 |
National Research Council of Canada |
发明人 |
Conlan Joseph Wayne;Sjostedt Anders |
| 分类号 |
C12N1/20;A61K39/02;C12N9/90;C12N9/10 |
主分类号 |
C12N1/20 |
| 代理机构 |
|
代理人 |
Lemay Catherine |
| 主权项 |
1. An attenuated Francisella tularensis mutant strain wherein the caseinolytic peptidase B (c/pB) gene is deleted, wherein the mutant is a variant of the wild-type clinical strain of F. tularensis selected from the group consisting of SCHU S4, FS033, FSC 108 and FSC 200. |
| 地址 |
Ottawa, ON. CA |
