Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-I, reduce monocyte migration into tumors, and reduce the accumulation of tumor-associated macrophages.
申请公布号
SG10201500328Q(A)
申请公布日期
2015.03.30
申请号
SG10201500328Q
申请日期
2008.08.19
申请人
AMGEN INC.
发明人
BRASEL, KENNETH, ALLAN;FOSTER, STEPHEN;CERRETTI, DOUGLAS, PAT;SUN, JILIN;SMOTHERS, JAMES, F.;MEHLIN, CHRISTOPHER