发明名称 |
MITOCHONDRIAL TOXICITY TEST |
摘要 |
<p>A novel method useful in drug screening. The method is useful for testing effects of substances on the mitochondria, notably toxic or beneficial effects of drug substances or candidate drug substances. The method is based on measurement in live human mitochondria ex vivo, but in a setting as near the in vivo situation as possible. The method is also useful for testing substances impact on the mitochondrial respiration. The method can be used to i) screening and selection of early or late stage drug candidates in cells derived from blood from healthy individuals or in so-called buffy coat, which is a concentrated solution of platelets and white blood cells, ii) testing a patient's sensitivity to a known mitochondrial toxicant, iii) analysing mitochondrial drug toxicity in clinical trials, and/or iv) analysing beneficial effects of drugs intended to improve mitochondrial function</p> |
申请公布号 |
SG11201501345X(A) |
申请公布日期 |
2015.03.30 |
申请号 |
SGX11201501345 |
申请日期 |
2013.10.04 |
申请人 |
NEUROVIVE PHARMACEUTICAL AB |
发明人 |
SJÖVALL, FREDRIK;EHINGER, JOHANNES;HANSSON, MAGNUS;ELMER, ESKIL;BATCHELLER, DEREK GREGORY |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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