| 主权项 |
1. A toxin peptide capable of selectively inhibiting a Kv1.3 potassium channel protein,
said peptide having or consisting essentially of 32 to 36 amino acid residues, more preferably 33, 34 or 35 amino acid residues) said peptide having four disulphide bridges, wherein said peptide comprises the following amino acid sequence:12345678910ZX1X2C1X3X4X5X6X7C211121314151617181920X8X9X10C3X11X12X13K1C4T121222324252627282930X14G1K2C5X15N1R1K3C6X163132333435C7T1N2C8X17whereinPos.1Z is pyroglutamate, glutamate (E), aspartate (D), asparagine (N)or glutamine (Q),2X1 is lysine (K) or arginine (R) or nothing,3X2 is glutamate (E) or aspartate (D) or nothing4C1 is cysteine5X3 is threonine (T) or serine (S)6X4 is glycine (G) or alanine (A)7X5 is proline (P) or serine (S)8X6 is glutamine (Q), asparagine (N), glutamate (E), aspartate (D)or lysine (K)9X7 histidine (H), phenylalanine (F), aspartate (D) or glutamine (Q)10C2 is cysteine11X8 is threonine (T), serine (S), alanine (A), leucine (L) orisoleucine (I),12X9 is asparagine (N), glutamate (E), glutamine (Q) or lysine (K),13X10 is phenylalanine (F), proline (P) or histidine (H),14C3 is cysteine15X11 is lysine (K) or arginine (R),16X12 is lysine (K) or aspartate (D) wherein preferably ifX12 is lysine (K) then X13 is alanine (A)or asparagine (N), whereas if X12 is aspartate (D) thenX13 is asparagine (N)17X13 is alanine (A) or asparagine (N) wherein preferably ifX12 is lysine (K) then X13 is alanine (A)or asparagine (N), whereas if X12 is aspartate (D) thenX13 is asparagine (N)18K1 is lysine (K)19C4 is cysteine20T1 is threonine (T)21X14 is histidine (H) or tyrosine (Y)22G1 is glycine23K2 is lysine (K)24C5 is cysteine,25X15 is methionine (M), threonine (T) or norleucine (Nor),26N1 is asparagine,27R1 is arginine (R)28K3 is lysine29C6 is cysteine,30X16 is lysine (K) or glycine (G)31C7 is cysteine,32T1 is threonine,33N2 is asparagine (N)34C8 is cysteine,35X17 is lysine (K) or arginine (R) |
