Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives

摘要

The invention encompasses a compound derived from hydroxamic acid that may be used to slow the expansion of cancer cells and thus is effective in the treatment of cancer. Generally, the disclosed compound includes a benzimidazole group coupled to a hydroxyamide of five or more unsubstituted carbon atoms and any pharmaceutically acceptable salts, solvates and chemically protected forms thereof. Also disclosed are pharmacological compositions including the compound and methods of using the compound to slow the expansion of cancer cells as well as methods of using the compound to treat cancer.

主权项

1. A compound with the formula: wherein X is selected from the group consisting of H, methyl, cyclopropyl, and cyclopentyl; wherein Q is H; wherein Z is selected from the group consisting of H, halo, phenyl, halophenyl, 4-methoxyphenyl, 4-dimethylaminophenyl, 5-pyrimidyl, methoxy, and dimethylamino; and wherein m is an integer selected from the group consisting of 5 and 6.