发明名称 |
Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof |
摘要 |
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival. |
申请公布号 |
US8987210(B2) |
申请公布日期 |
2015.03.24 |
申请号 |
US201313962401 |
申请日期 |
2013.08.08 |
申请人 |
Jyant Technologies, Inc. |
发明人 |
Lillard, Jr. James W. |
分类号 |
A61K38/00;A61K38/16;C07K1/00;C07K16/28;C07K14/52 |
主分类号 |
A61K38/00 |
代理机构 |
Andrews Kurth LLP |
代理人 |
Wang Ping;Andrews Kurth LLP |
主权项 |
1. An isolated chemokine-immunoglobulin fusion polypeptide, comprising:
a CCL25 chemokine moiety and an immunoglobulin moiety comprising a constant region of a human immunoglobulin or a functional variant thereof, wherein the chemokine-immunoglobulin fusion polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:64, SEQ ID NO:65 and SEQ ID NO:66. |
地址 |
Marietta GA US |