| 发明名称 | Nitroxyl donors with improved therapeutic index | ||
| 摘要 | The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure. | ||
| 申请公布号 | US8987326(B2) | 申请公布日期 | 2015.03.24 |
| 申请号 | US201414158456 | 申请日期 | 2014.01.17 |
| 申请人 | Cardioxyl Pharmaceuticals, Inc. | 发明人 | Kalish Vincent Jacob;Brookfield Frederick Arthur;Courtney Stephen Martin;Frost Lisa Marie;Toscano John P. |
| 分类号 | A61K31/341;A61K31/18;C07D307/64;C07C311/15;C07C317/14 | 主分类号 | A61K31/341 |
| 代理机构 | Dechert LLP | 代理人 | Dechert LLP |
| 主权项 | 1. A compound of formula (1): | ||
| 地址 | Chapel Hill NC US | ||