METHOD FOR CELL PROTECTION AGAINST HYPOXIC INJURY BY GLUTATHIONYLATION OF Na, K-ADENOSINE TRIPHOSPHATASE CATALYTIC SUBUNIT

摘要

FIELD: medicine.SUBSTANCE: invention refers to methods for cell and tissue protection against a hypoxic injury and can be used for developing remedies for hypoxic and ischemic injuries. The developed method for protection is based on cell treatment by substances increasing a level of glutathionylation of Na,Kthat reduces to its activation. The obtained results can be actual for biological research institutions, medical facilities, particularly cardiologic clinics, as well as biotechnological companies for transplantology and tissue engineering.EFFECT: presented method can be used for research activities aiming at creating the therapeutic agents for relieving tissue injuries, particularly myocardial tissue in hypoxia and hypoxia/reoxygenation.6 dwg