| 发明名称 |
TREATMENT OF ACUTE INFLAMMATION IN THE RESPIRATORY TRACT |
| 摘要 |
This invention relates to the field of molecular physiology. Specifically, this invention relates to the prevention and/or treatment of acute inflammation of the respiratory tract, especially acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Levels of CCL7 have been demonstrated to be increased in patients suffering from such conditions and animal models of such conditions. Antagonists of CCL7 and/or other members of the PAR1-CCL7 axis, or CCL2 can be used to prevent and/or treat these conditions. |
| 申请公布号 |
US2015079105(A1) |
申请公布日期 |
2015.03.19 |
| 申请号 |
US201314389718 |
申请日期 |
2013.03.15 |
| 申请人 |
UCL Business PLC |
发明人 |
Chambers Rachel;Mercer Paul;Williams Andrew |
| 分类号 |
A61K39/395;A61K38/00;A61K31/7105;C07K16/24;C12N15/113 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antagonist of:
(a) CCL7, PAR1 or another member of the PAR1-CCL7 axis; or (b) CCL2; for use in the treatment or prevention of acute inflammation associated with the accumulation of neutrophils in the respiratory tract. |
| 地址 |
London GB |
