Flavonoid dimers and their use

摘要

This invention relates to bis-flavonoid compounds, their synthesis and use for inhibiting multidrug resistance in chemotherapy and protozoan infection, wherein the bis-flavonoids compounds have the formula:;

主权项

1. A compound of formula II:or a pharmaceutically acceptable salt or solvate thereof,
wherein Y is N—R1 R1 is independently selected from the group consisting of H, alkyl, alkenyl, alkoxy, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, —(CH2)q-aryl, —(CH2)q-heteroaryl, —(CH2)q-cycloalkyl, (CH2)q-cycloalkenyl, —(CH2)q-heterocycloalkyl, —(CH2)q-heterocycloalkenyl, —C(O)-alkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)-cycloalkyl, —C(O)-cycloalkenyl, —C(O)-heterocycloalkyl, —C(O)-heterocycloalkenyl, —C(O)O-alkyl, —C(O)O-aryl, —C(O)O-heteroaryl, —C(O)O-cycloalkyl, —C(O)O-cycloalkenyl, —C(O)O-heterocycloalkyl, —C(O)O-heterocycloalkenyl, —S-alkyl, —S-aryl, —S-heteroaryl, —S-cycloalkyl, —S-heterocycloalkyl, —SO-alkyl, —SO-aryl, —SO-heteroaryl, —SO-cycloalkyl, —SO-heterocycloalkyl, —SO2-alkyl, —SO2-aryl, —SO2-heteroaryl, —SO2-cycloalkyl, or —SO2-heterocycloalkyl, any of which may be optionally substituted; R2 and R′2 are each independently selected from the group consisting of H, OH, halogen, alkyl, alkenyl, alkoxy, aryloxy, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, —O—(CH2)q-aryl, —(CH2)q-cycloalkyl, —(CH2)q-heterocycloalkyl, —(CH2)q-aryl, —(CH2)q-heteroaryl, —C(O)-alkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, —C(O)O-alkyl, —C(O)O-aryl, —C(O)O-heteroaryl, —C(O)O-cycloalkyl, or —C(O)O-heterocycloalkyl, any of which may be optionally substituted; n, and m are independently an integer from 1 to 6; X is selected from CH2, O or N—R1; R3; R′3; R5; R′5; R6; R′6; R7; R′7; Rs; R′8 are each independently H, OH, halogen, alkyl, alkenyl, alkoxy, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, aryloxy, —O—(CH2)q-aryl, —(CH2)q-aryl, —C(O)-alkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, —C(O)O-alkyl, —C(O)O-aryl, —C(O)O-heteroaryl, —C(O)O-cycloalkyl, or C(O)O-heterocycloalkyl, nitro, amino, cyano, nitroso, or azido group, any of which may be optionally substituted; and q is an integer from 1 to 6.