| 摘要 |
The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders. |
| 主权项 |
1. A compound of formula (I) in which R1 represents hydrogen or fluorine, L1 represents ethane-1,2-diyl or 1,4-phenylene, and A represents a group of the formula in which * denotes the respective point of attachment to the remainder of the molecule, L2 represents straight-chain (C1-C6)-alkanediyl, L3 represents a bond, —O—, —CH2—, —CH2—CH2— or —CH═CH—, R2 represents (C1-C4)-alkyl which may be substituted up to six times by fluorine,
orrepresents (C3-C6)-cycloalkyl which may be mono- or disubstituted by identical or different radicals selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl and (C1-C4)-alkyl,orrepresents 4- to 6-membered heterocyclyl which contains one or two identical or different hetero ring members selected from the group consisting of N(R4), O, S and S(O)2 where
R4 represents (C1-C4)-alkyl or (C1-C4)-alkylcarbonyl or, in the case that N(R4) represents a ring nitrogen atom by means of which said heterocyclyl is attached to the adjacent phenyl group, is not present,orrepresents 5-membered heteroaryl which contains one, two or three identical or different ring heteroatoms selected from the group consisting of N, O and S and may optionally be fused to a phenyl ring,
where the heteroaryl ring and the optionally fused phenyl ring may each be mono- or disubstituted by identical or different radicals selected from the group consisting of fluorine, chlorine, difluoromethyl, trifluoromethyl, and (C1-C4)-alkyl,or represents chlorine, and R3A, R3B, R3C and R3D independently of one another represent hydrogen or a substituent selected from the group consisting of fluorine, chlorine, bromine, cyano, (C1-C4)-alkyl, difluoromethyl, trifluoromethyl, (C1-C4)-alkoxy, difluoromethoxy and trifluoromethoxy, and salts, solvates and solvates of the salts thereof. |
