发明名称 |
NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS THEREOF |
摘要 |
<p>In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 m M histidine, and about 150 m M sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.</p> |
申请公布号 |
WO2015033251(A2) |
申请公布日期 |
2015.03.12 |
申请号 |
WO2014IB64091 |
申请日期 |
2014.08.27 |
申请人 |
PFIZER INC. |
发明人 |
ANDERSON, ANNALIESA SYBIL;ARUMUGHAM, RASAPPA GOUNDER;FARLEY, JOHN ERWIN;FLETCHER, LEAH DIANE;HARRIS, SHANNON;JANSEN, KATHRIN UTE;JONES, THOMAS RICHARD;KHANDKE, LAKSHMI;LOUN, BOUNTHON;PEREZ, JOHN LANCE;ZLOTNICK, GARY WARREN |
分类号 |
A61K39/095 |
主分类号 |
A61K39/095 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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