发明名称 |
TCR/MHCII-COLLAGEN INTERACTION INHIBITORS USEFUL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS |
摘要 |
The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen ll-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis. |
申请公布号 |
US2015073030(A1) |
申请公布日期 |
2015.03.12 |
申请号 |
US201314389759 |
申请日期 |
2013.04.02 |
申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE ;UNIVERSITÀ CATTOLICA DEL SACRO CUORE |
发明人 |
De Rosa Maria Cristina;Ria Francesco;Giardina Bruno;Ferraccioli Gianfranco;Pirolli Davide;Nicolo' Chiara |
分类号 |
C07D407/12;C07D209/86;C07D207/08 |
主分类号 |
C07D407/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Roma IT |