| 主权项 |
1. A method of treating a respiratory syncytial viral (RSV) infection comprising administering to a subject in need thereof an anti-virally effective amount of a compound of formula I, or a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; wherein each X independently is C or N; R1 is selected from the group of H, halogen, C1-C6alkyl, C3-C7cycloalkyl, C1-C6alkoxy, N(R6)2, CO(R7), CH2NH2, CH2OH, CN, C(═NOH)NH2, C(═NOCH3)NH2, C(═NH)NH2, CF3, OCF3, and B(OH)2; B(O—C1-C6alkyl)2; R2 is selected from the group consisting of H, halogen, C1-C6alkyl, C3-C7cycloalkyl, C1-C6alkoxy, and CO(R7); R3 is —(CR8R9)n—R10; R4 is selected from the group consisting of H, C1-C10alkyl, C3-C7cycloalkyl, C2-C10alkenyl, SO2—R8, CH2CF3, SO2CH3 or a 4 to 6 membered saturated ring containing an oxygen atom; R5 is present where X is C, and is selected from the group consisting of H, C1-C6alkyl, C3-C7cycloalkyl, C1-C6alkoxy, CO(R7), CF3 and halogen; R5 is absent where X is N; R6 is selected from the group consisting of H, C1-C6alkyl, COOCH3, and CONHSO2CH3; R7 is selected from the group consisting of OH, O(C1-C6alkyl), NH2, NHSO2N(C1-C6alkyl)2, NHSO2NHCH3, NHSO2(C1-C6alkyl), NHSO2(C3-C7cycloalkyl), and N(C1-C6-alkyl)2, NR8R9, NR9R10; n is an integer from 2 to 6; R8 and R9 are each independently chosen from H, C1-C10alkyl, C3-C7cycloalkyl or R8 and R9 taken together form a 4 to 6 membered aliphatic ring that optionally contains one or more heteroatoms selected from the group N, S, O; R10 is selected from the group consisting of H, C1-C6alkyl, OH, CN, F, CF2H, CF3, C(═NOH)NH2, CONR8R9, COORS, CONR8SO2R9, CON(R8)SO2N(R8R9), NR8R9, NR8COOR9, OCOR8, NR8SO2R9, SO2NR8R9, SO2R8 or a 4 to 6 membered saturated ring containing an oxygen atom. |
