发明名称 |
ANTI-P-SELECTIN ANTIBODIES AND METHODS OF THEIR USE AND IDENTIFICATION |
摘要 |
Antibodies are disclosed which bind specifically to P-selectin, block the binding of PSGL-1 to P-selectin, and cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of acute and chronic inflammatory and thrombotic disorders and conditions. Screening methods for identifying and characterizing such antibodies are also disclosed. |
申请公布号 |
EP2654781(A4) |
申请公布日期 |
2015.03.11 |
申请号 |
EP20110851933 |
申请日期 |
2011.12.21 |
申请人 |
SELEXYS PHARMACEUTICALS CORPORATION;OKLAHOMA MEDICAL RESEARCH FOUNDATION |
发明人 |
ROLLINS, SCOTT;ALVAREZ, RICHARD;ROTHER, RUSSELL;KAWAR, ZIAD, S.;MCEVER, RODGER, P. |
分类号 |
C07K16/28;A61P7/02;A61P7/06;A61P37/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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