| 发明名称 |
METHODS AND COMPOSITIONS FOR 6-PHOSPHOGLUCONATE DEHYDROGENASE (6-PGD) AS A TARGET FOR LUNG CANCER THERAPY |
| 摘要 |
The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing a proliferative disease that result in dysregulation of 6-phosphogluconate dehydrogenase. In particular, the methods and compositions include treatment of gefitinib/erlotinib resistant proliferative diseases such as lung cancer using a 6-phosphogluconate dehydrogenase antagonist. |
| 申请公布号 |
US2015064200(A1) |
申请公布日期 |
2015.03.05 |
| 申请号 |
US201314390252 |
申请日期 |
2013.04.04 |
| 申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
Sukhatme Vikas P.;Chang Barden Chunkong |
| 分类号 |
A61K39/395;C12Q1/32;A61K45/06;A61K31/7088 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a subject having a proliferative disease, said method comprising administering to said subject a 6-phosphogluconate dehydrogenase antagonist in an amount sufficient to treat said proliferative disease. |
| 地址 |
Boston MA US |
