Agent for applying to mucosa and method for the production thereof

摘要

An agent for applying to mucosa capable of persistently exerting a therapeutic effect on disorders such as inflammation and lesions in the mucosa even by a lower frequency of administration because the agent can stay at a diseased site for a long period of time by exhibiting a high staying property in a mucosal epithelial layer is provided, said agent for application to mucosa containing glycosaminoglycan (GAG) into which a hydrophobic group is introduced via a binding chain, as an active ingredient.

主权项

1. A method for the reduction of a corneal epithelial layer disorder, comprising administering to a subject in need thereof an effective amount of a glycosaminoglycan into which a hydrophobic group is introduced via a binding chain into a repeating unit of the glycosaminoglycan with a degree of substitution of 10% to 20% in molar equivalent of the glycosaminoglycan, wherein the glycosaminoglycan is hyaluronic acid or a salt thereof, the binding chain is —CONH—, the hydrophobic group is a phenylethenyl group, the glycosaminoglycan into which a hydrophobic group is introduced via a binding chain further includes a spacer chain between the binding chain and the hydrophobic group, wherein the spacer chain is —(CH2)3—OC(═O)—,
wherein said glycosaminoglycan into which a hydrophobic group is introduced contains repeating units of formula (I): wherein R is —OH, —NH—(CH2)3—OC(═O)—CH═CH—Ph, or a salt of said —OH, and wherein said corneal epithelial layer disorder is corneal xerosis, keratoconjunctivitis, superficial punctate keratitis, corneal epithelial erosion, or corneal epithelial loss.