| 摘要 |
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine derivative compounds, substituted 3-aminopyridazine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like. |
| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof,wherein,
X is O or NR5; R1 is hydrogen or alkyl; each R3 is independently selected from hydroxy, halogen, cyano, NH2, NHR4, N(R4)2, NHC(O)R4, NHC(O)OR4, NHC(O)NHR4, NHC(O)N(R4)2, NHS(O)2R4, NR4C(O)R4, NR4C(O)OR4, NR4C(O)NHR4, NR4C(O)N(R4)2, NR4S(O)2R4, alkyl, alkenyl, alkynyl, alkoxy, aryl, aryloxy, aralkyl, carbocyclyl, heterocyclyl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, or heteroarylalkyl; each R4 is independently selected from alkyl, aryl, aralkyl, carbocyclyl, heterocyclyl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, or heteroarylalkyl; R5 is alkyl, alkenyl, alkynyl, aryl, aralkyl, carbocyclyl, heterocyclyl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, or heteroarylalkyl; and n is an integer selected from 0, or 1. |
