发明名称 |
Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient |
摘要 |
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Cyclopropyl-3-fluoro-4-methyl-5[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-benzamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a β2 adrenoceptor agonist; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DPI antagonist; an Histone Deacetylase activator; an IKK2 kinase inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; a MABA compound; an MPO inhibitor; a muscarinic antagonist; a PDE4 inhibitor; a PPARγ agonist; a protease inhibitor; a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease. |
申请公布号 |
US8969350(B2) |
申请公布日期 |
2015.03.03 |
申请号 |
US200913140477 |
申请日期 |
2009.12.17 |
申请人 |
Astrazeneca AB |
发明人 |
Cooper Anne Elizabeth;Luker Timothy Jon;Schmidt Jerzy Andrzej |
分类号 |
A61K31/50;A61K31/501;A61K45/06;A61K31/416;A61K31/444;A61K31/4545;A61K31/4965 |
主分类号 |
A61K31/50 |
代理机构 |
Harness, Dickey & Pierce, P.L.C. |
代理人 |
Harness, Dickey & Pierce, P.L.C. |
主权项 |
1. A pharmaceutical product comprising:
N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-benzamide or a salt thereof, and budesonide. |
地址 |
Sodertalje SE |