| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a number of substituted dihydrobenzocycloalkyloxymethyl oxazolpyrimidinone of formulawherein n represents 1, 2 or 3; Rrepresents hydrogen, methyl, fluoromethyl, ethyl, 2-fluoroethyl and propyl; Ris specified in a group consisting of hydrogen, methyl, fluoromethyl, ethyl, 2-fluoroethyl, propyl, 1,1-difluoropropyl, methoxymethyl and 2-fluoroethoxymethyl; Rand Rrepresent (C-C)alkyl; and Rand Rare identical or different and are independently specified in a group consisting of hydrogen, halogen, (C-C)alkyl and (C-C)alkoxy. The invention also refers to specific compounds specified in cl.8 of the patent claim, to compounds of formulaa pharmaceutical composition and the use of the declared compounds.EFFECT: dihydrobenzocycloalkyl-oxymethyloxazolpyrimidinone as metabotropic glutamate receptor mGluR2 modulators.14 cl, 1 tbl, 15 ex |
