| 摘要 |
Disclosed is an isolated antibody or antigen-binding fragment thereof that binds to a free C5a polypeptide, wherein the free C5a is a human polypeptide (hC5a) having the amino acid sequence depicted in SEQ ID NO: 1, and wherein the antibody or antigen-binding fragment thereof binds to the free hC5a polypeptide in vitro with a KD that is less than 1.25 x 10-9 M in the presence of a molar excess of uncleaved, native human C5 and comprises: - a light chain polypeptide comprising: (i) a light chain CDR1 comprising the amino acid sequence depicted by RASESVDSYGNSFMH; a light chain CDR2 comprising the amino acid sequence depicted by RASNLES or WASTRES; and a light chain CDR3 comprising the amino acid sequence depicted by QQSNEDPYT; and - a heavy chain polypeptide comprising: (i) a heavy chain CDR1 comprising the amino acid sequence depicted in DYSMD; a heavy chain CDR2 comprising the amino acid sequence depicted in AINPNSGGTNYNQKFKD or AIHLNTGYTNYNQKFKG; and a heavy chain CDR3 comprising the amino acid sequence depicted in SGSYDGYYAMDY or GFYDGYSPMDY. |
