METHOD OF ALTERING THE IMMUNDOMINANCE HIERARCHY OF HIV GAG BY DNA VACCINE EXPRESSING CONSERVED REGIONS

摘要

The invention provides methods and compositions for eliciting broad immune responses. The methods employ nucleic acid vaccines that encodes highly conserved elements from a virus.

主权项

1. A method of inducing an immune response in a subject, the method comprising administering a first Gag conserved element nucleic acid that encodes a first Gag conserved element polypeptide that comprises six conserved elements from Gag to the subject, wherein the conserved elements are from different regions of Gag, and further, wherein each conserved element is at least 12 amino acids in length, but less than 30 amino acids in length and the conserved elements are not contiguous; and
administering a nucleic acid encoding a full-length Gag protein.