发明名称 |
COMPOSITIONS AND METHODS FOR THE MODULATION OF SPECIFIC AMIDASES FOR N-ACYLETHANOLAMINES FOR USE IN THE THERAPY OF INFLAMMATORY DISEASES |
摘要 |
The present invention regards compositions and methods for the modulation of amidases capable of hydrolysing N-acylethanolamines useable in the therapy of inflammatory diseases. In particular, the present invention regards a compound of general formula (I): enantiomers, diastereoisomers, racemes and mixtures, polymorphs, salts, solvates thereof, wherein: (a) R is a linear alkyl radical having 13 to 19 carbon atoms or alkenyl radical having 13 to 19 carbon atoms carrying a double bond; (b) X is 0 or S; (c) Y is a 2 or 3 carbon atom alkylene residue, optionally substituted with one or two groups equal or different from each other and selected from among the group consisting of: —CH3, —CH2OH, —COOCH3, —COOH. Y may preferably be: —CH2—CH2—, —CH2—CH2—CH2—, CH(CH3)—CH2—, —CH2—CH(CH3)—, —CH2—C(CH3)2—, —CH2—CH(CH2OH)—, —CH2—C((CH2OH)2)—, —CH═CH—, —CH2—CH(COOCH3)—, —CH2—CH(COOH)—, for use as a medicine.; |
申请公布号 |
US2015057269(A1) |
申请公布日期 |
2015.02.26 |
申请号 |
US201214378185 |
申请日期 |
2012.02.17 |
申请人 |
Della Valle Francesco;Della Valle Maria Federica;Marcolongo Gabriele;Di Marzo Vincenzo;Cuzzocrea Salvatore |
发明人 |
Della Valle Francesco;Della Valle Maria Federica;Marcolongo Gabriele;Di Marzo Vincenzo;Cuzzocrea Salvatore |
分类号 |
C07D263/12;A61K31/164;C07D263/14;C07D263/32;A61K31/535;C07D277/10;A61K31/426;A61K31/421;C07D265/06 |
主分类号 |
C07D263/12 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of general formula (I):enantiomers, diastereoisomers, racemes and mixtures, polymorphs, salts, solvates thereof, wherein:
(a) R is a linear alkyl radical having 13 to 19 carbon atoms or alkenyl radical having 13 to 19 carbon atoms carrying a double bond; (b) X is O or S; (c) Y is a 2 or 3 carbon atom alkylene residue, optionally substituted with one or two groups equal or different from each other and selected from among the group consisting of: —CH3, —CH2OH, —COOCH3, —COOH, Y may preferably be: —CH2—CH2—, —CH2—CH2—CH2—, —CH(CH3)—CH2—, —CH2—CH(CH3)—, —CH2—C(CH3)2—, —CH2—CH(CH2OH)—, —CH2—C((CH2OH)2)—, —CH═CH—, —CH2—CH(COOCH3)—, —CH2—CH(COOH)—, for use as a medicine. |
地址 |
Milano IT |