MRI contrast agent coated with carboxylated mannan and method for producing the same

摘要

The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.

主权项

1. A superparamagnetic nanoparticle MRI contrast agent coated with carboxylated mannan that has a ring-opened dicarboxylate unit having a formulain between some of the mannose monomers, for visualizing antigen presenting cells and the tissue containing such antigen presenting cells specifically in MRI.