| 摘要 |
本发明系关于式I之乙炔基衍生物;其中Y 系N或CH；R 1 系氢、氟或氯；及R 2 系氢或低碳数烷基；或其医药上可接受之酸加成盐。;现已令人惊奇地发现，通式I之化合物为代谢型榖胺酸受体拮抗剂(负向异位调节剂)，其用于治疗焦虑及疼痛、抑郁、X染色体脆折症侯群、自闭症谱系障碍、帕金森氏病(Parkinson's disease)及胃食道逆流病(GERD)。; R 1 is hydrogen, fluoro or chloro; and R 2 is hydrogen or lower alkyl; or to a pharmaceutically acceptable acid addition salt thereof. ;It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson’s disease, and gastroesophageal reflux disease (GERD). |
