MICROWAVE STERILIZATION OF PHARMACEUTICAL CYANOACRYLATE ESTERS COMPOSITIONS

摘要

A method for sterilizing a cyanoacrylate composition comprises exposing it to microwaves. The method can further comprise post-heating the composition after microwave exposure, and/or cooling the composition after post-heating it. In addition, a system for sterilizing a cyanoacrylate composition comprises a sterilizing chamber, a microwave generator. The system can further comprise an infrared thermometer, a post-heating chamber, a heater thermometer, a cooling mechanism, and/or a belt. In some embodiments, the belt is configured to move sample vials containing cyanoacrylate to and from the sterilizing chamber, and to and from the post-heating chamber.

主权项

1. A method of sterilizing cyanoacrylate, the method comprising:
providing a first container comprising a first cyanoacrylate composition; moving the first container along a first pathway into a microwave chamber; exposing the first cyanoacrylate composition within the microwave chamber to microwave energy with a power of between about 0.1 kW to about 12 kW and at a temperature of less than about 190° C. for no more than about 30 seconds, such that a Bacillus subtilis count in the composition does not exceed 10−6; and moving the first container along a second pathway out of the microwave chamber.