Certain compounds, compositions and methods

摘要

The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.

主权项

1. A composition comprising:
(i) a compound of Formula I or a pharmaceutically acceptable salt thereof:wherein the carbon marked by an asterisk may have an (R) or an (S) configuration; and wherein R1 and R2 are fluoro;
(ii) a CDA substrate drug; and (iii) at least one additional chemotherapeutic agent;as a combination for simultaneous, separate, or sequential administration.