发明名称 |
LIPOSOMAL FORMULATIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS |
摘要 |
The present disclosure relates to liposomal formulations of aminoglycoside such as gentamicin, the method of making and method of using such formulations. The aminoglycoside liposomal formulations disclosed have higher drug to lipid loading ratio, and enable the formulations to be used to treat infections caused by bacterial species resistant to common antibiotics. In one embodiment, a gentamicin liposome formulation with a gentamicin to phospholipid ratio of 10:1 to 26:1 has been prepared and shown to be effective at treating infections caused by R. equi. |
申请公布号 |
WO2015017807(A1) |
申请公布日期 |
2015.02.05 |
申请号 |
WO2014US49448 |
申请日期 |
2014.08.01 |
申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
GIGUERE, STEEVE;ARNOLD, ROBERT D. |
分类号 |
A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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