Intrabuccally rapidly disintegrating tablet and a production method of the tablets

摘要

An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

主权项

1. A method of producing an intrabuccally rapidly disintegrating tablet, said intrabuccally rapidly disintegrating tablet comprising:
a sugar alcohol or saccharide in the form of primary particles having an average particle size of not more than 30 μm; an active ingredient; and one or more disintegrants selected from the group consisting of crosspovidone, crosscarmellose sodium, low substituted hydroxypropylcellulose, and a mixture thereof, said method comprising the steps of: (a) mixing a powder material comprising the sugar alcohol or saccharide, said active ingredient and said one or more disintegrants; (b) granulating the mixture of step (a), thereby producing granulated material having a predetermined particle size; and (c) compressing the granulated mixture into an intrabuccally rapidly disintegrating tablet.