PROCESS FOR PRODUCING OXIMES OF 7-BRACKET-AMINO-THIAZOLYL-ACETAMIDO-BRACKET CLOSED-3-ACETOXYMETHYL-CEPH-3-EME-4-CARBOXYLIC ACID MIDO-SKOBKA ZAKRYTA-3-ACETOKSIMETIL-CEF-3-EM-4-KARBONOVO

摘要

The compounds correspond to the formula: in which R'c represents hydrogen or a C1-C4 alkyl, alkenyl or alkynyl. They are prepared by reacting the 7-aminocephalosporanic acid first with the syn isomer of a 2-(2-Rd-amino-4-thiazolyl)-2-(R'd-oxyimino)acetic acid or of a functional derivative of this acid; Rd and R'd represent groups which can be removed by acid hydrolysis or by hydrogenolysis, or chloroacetyl groups, it being possible for R'd to additionally represent a C1-C4 alkyl, alkenyl or alkynyl. An acid hydrolysis or a hydrogenolysis is then carried out or, in the case of chloracetyl groups, a treatment with thiourea. The compounds and their salts of the carboxylic group have a good antibiotic activity and can be used for the treatment of various infectious diseases.