| 摘要 |
The invention relates to substituted benzamide derivatives with a general formula I where А1 and А2 are -N or -СН, so that if А1 is -N, А2 is -СН and if А2 is -N, then А1 is -СН; R is hydrogen, -(С1-С3)-alkyl with a straight or branched chain, -(С1-С3)-alkyl, where one, two, or three hydrogen atoms can be substituted by a halogen atom or hydroxyl group, -(С1-С3)-O-(С1-С3), -(С1-С3)-O-(С1-С3), where one, two, or three hydrogen atoms can be substituted by a halogen atom or is a group with a general formula where R3 and R4 are simultaneously or independently of each other halogen, hydroxy, -(С1-С3)-alkyl, -(С1-С3)-alkyl, in whose molecule one, two, or three hydrogen atoms can be substituted by a halogen atom or hydroxyl group, -О-(С1-С3)-alkyl, -О-(С1-С3)-alkyl, in whose molecule one, two, or three hydrogen atoms can be substituted by a halogen atom, -О-(С1-С3)-О-(С1-С3), -О-(С1-С3)-О-(С1-С3), where one, two, or three hydrogen atoms can be substituted by a halogen atom; R1 and R2 simultaneously or independently of each other are halogen, hydroxy, -(С1-С3)-alkyl and -(С1-С3)-alkyl, where one, two, or three hydrogen atoms can be substituted by a halogen atom or hydroxyl group, -О-(С1-С3)-alkyl, -О-(С1-С3)-alkyl, where one, two, or three hydrogen atoms can be substituted by a halogen atom, -О-(С1-С3)-О-(С1-С3), -О-(С1-С3)-О-(С1-С3), where one, two, or three hydrogen atoms can be substituted by a halogen atom, as well as their pharmaceutically acceptable salts, isomers or their mixtures. The compounds are applicable as in vitro selective МАО-В inhibitors for the prevention and treatment of acute and chronic neurological, cognitive, and neurodegenerative diseases, and particularly for the prevention and treatment of Parkinson's disease and Alzheimer's. 4 claims, 1 figure |
