发明名称 |
HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 |
摘要 |
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R 1 is hydroxy or hydrogen; R 2 is hydroxy; methoxy or hydrogen; provided that at least one of R 1 and R 2 is hydroxy; R 3 is selected from hydrogen; halogen; cyano; optionally substituted C 1-5 hydrocarbyl and optionally substituted C 1-5 hydrocarbyloxy; R 4 is selected from hydrogen; a group -(O) n -R 7 where n is 0 or 1 and R 7 is an optionally substituted acyclic C 1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C 1-5 hydrocarbylamino; or R 3 and R 4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR 5 R 6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors. |
申请公布号 |
SI2332909(T1) |
申请公布日期 |
2015.01.30 |
申请号 |
SI20060031846T |
申请日期 |
2006.04.13 |
申请人 |
ASTEX THERAPEUTICS LIMITED |
发明人 |
CHESSARI GIANNI;CONGREVE MILES STUART;NAVARRO EVA FIGUEROA;FREDERICKSON MARTYN;MURRAY CHRISTOPHER;WOOLFORD ALISON JO-ANN;CARR MARIA GRAZIA;DOWNHAM ROBERT;O'BRIEN MICHAEL ALISTAIR;PHILLIPS THERESA RACHEL;WOODHEAD ANDREW JAMES |
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