摘要 |
The antibiotics Papulacandin A and Papulacandin B are etherified at the phenolic groups in positions 10 and/or 12 by introducing a group -CH2-K wherein K is a hydrocarbon radical which is either unsaturated and aliphatic, or it is saturated or unsaturated and substituted by cyclic hydrocarbons, such as aromatic or heterocyclic ones, or by functional groups, such as halogens, carboxyl groups, carboxyl ester or amide groups. These ethers are characterized by a good antifungal action e.g. against Candida albicans and also by an antifiral action.
|