发明名称 |
CARBONIC ANHYDRASE IX (G250) ANTIBODIES AND METHODS OF USE THEREOF |
摘要 |
The invention provides scFv antibodies and monoclonal antibodies that bind to and decrease an activity of Carbonic Anhydrase IX (G250). Also provided are methods of treating and/or preventing cancer, such as renal clear cell cancer. Also provided are methods of identifying a carbonic anhydrase IX (G250) protein. The invention additionally provides methods of modifying immune effector cells, and the immune effector cells modified thereby. |
申请公布号 |
CA2632094(C) |
申请公布日期 |
2015.01.27 |
申请号 |
CA20062632094 |
申请日期 |
2006.12.04 |
申请人 |
DANA FARBER CANCER INSTITUTE, INC. |
发明人 |
MARASCO, WAYNE A.;LO, AGNES;XU, CHEN |
分类号 |
C07K16/40;A61K38/19;A61K39/395;A61K47/48;A61K48/00;A61K49/00;A61K51/10;A61P35/00;C07K14/55;C07K14/705;C07K16/46;C07K19/00;C12N5/10;C12N9/86;C12N15/12;C12N15/13;C12N15/26;C12N15/62;C12N15/85;G01N33/563;G01N33/573;G01N33/577 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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