发明名称 |
ARYLETHYNYL DERIVATIVES |
摘要 |
<p>The present invention relates to ethynyl derivatives of formula (I) wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms; selected from fluorine or chlorine; or to a pharmaceutically acceptable acid addition salt in enantiomerically pure form. It has been found that the compounds of general formula (I) are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).</p> |
申请公布号 |
PH12014502695(A1) |
申请公布日期 |
2015.01.26 |
申请号 |
PH12014502695 |
申请日期 |
2014.12.03 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
JAESCHKE, GEORG;LINDEMANN, LOTHAR;STADLER, HEINZ;VIEIRA, ERIC |
分类号 |
A61K31/403;A61P25/00;C07D209/52 |
主分类号 |
A61K31/403 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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