| 主权项 |
1. A chimeric flavivirus comprising sequences encoding capsid and non-structural proteins of a yellow fever virus and pre-membrane and envelope proteins of a dengue virus selected from a dengue-1 virus, a dengue-2 virus, a dengue-3 virus, and a dengue-4 virus, wherein the dengue virus envelope protein has a mutation in amino acid position 202 (dengue-3) or 204 (dengue-1, dengue-2, or dengue-4). |
